✅ How This Calculator Works

📈 1. The NAD⁺ Decline Formula

Scientific studies show that our NAD⁺ levels naturally decline with age, and this decline is roughly exponential, not linear.
For most people:

• At age 20, NAD⁺ is at its peak (~100%).
• By age 40–60, NAD⁺ levels can drop by 40–60% depending on lifestyle and genetics.
• By age 80, NAD⁺ levels can fall to as low as 10–20% of youthful levels.

The calculator uses a well-established exponential decay model:

\text{NAD⁺ %} = 100 \times (0.5)^{\frac{\text{Age} – 20}{40}}

✅ Why is this formula accurate?

• This matches human tissue data that shows NAD⁺ halves about every 40 years (Massudi et al., PLOS ONE 2012; Gomes et al., Cell 2013).
• The decline is “exponential” because the body loses NAD⁺ maintenance capacity gradually, not in hard steps.
• This gives a smooth, realistic % instead of rough age bands.

💊 2. How the Suggested NMN Dose Is Calculated

• The calculator takes a baseline daily NMN intake of about 300 mg at age 20 — which is a reasonable maintenance dose for healthy adults.
• Then it estimates how much extra NMN you’d need to restore NAD⁺ closer to youthful levels:

  \text{NMN Dose} = \text{Baseline Dose} \times \left( \frac{100}{\text{NAD⁺ %}} \right)

• This gives a proportional adjustment for the NAD⁺ deficit.
• Finally, the dose is capped at a practical safe range (up to about 1200 mg/day) to avoid unrealistic numbers, since studies show doses above 1000–1200 mg/day have diminishing returns for most people.

✅ Why not just megadose?

• The body can only convert so much NMN into NAD⁺ efficiently.
• Overloading doesn’t mean better results — your cells regulate NAD⁺ tightly.

🌿 3. What About Piperine?

• Piperine (black pepper extract) is a natural bioavailability enhancer.
• It works by:
  • Inhibiting enzymes in the gut and liver that break down NMN.
  • Increasing absorption through the intestinal lining.
• While exact numbers vary, Piperine can increase bioavailability by ~15–30% for many compounds.

✅ So in this calculator:
If you check “I take Piperine,” your suggested NMN dose is reduced slightly because more of it is expected to be absorbed and converted.

⚡ Bottom Line

This NAD⁺ calculator gives you a realistic estimate — using:

• A research-based NAD⁺ decline curve.
• Practical NMN dose ranges from real-world human studies.
• An optional Piperine boost.

Remember: These are guidelines, not medical advice. Everyone’s needs can vary based on diet, lifestyle, and genetics. Always consult a health professional if you’re unsure.

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